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. 2020 Nov 19;15(11):e0242513. doi: 10.1371/journal.pone.0242513

Fig 6. In-utero exposure to ART alters behaviour in the open field test in adulthood.

Fig 6

Speed of locomotion (A), total distance moved (B), distance moved in the centre of the arena (C), distance moved in the periphery (D), ambulatory time in the centre of the arena (E), ambulatory time in the periphery (F), rearing time (G), and resting time (H) for male and female mice exposed in-utero to control (CTRL, white bars), ATV/r/ABC/3TC (light grey bars), or ATV/r/TDF/FTC (dark grey bars). Data are mean ± SEM (n = 12–17 mice/group). One-way ANOVA with Bonferroni multiple comparisons tests was used to examine differences between control and treatment arms for each sex. $ indicates p<0.05 compared to control females. ATV/r, ritonavir-boosted atazanavir; ABC, abacavir; 3TC, lamivudine; TDF, tenofovir; FTC, emtricitabine; CTRL, control.