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Diagrams of MYC and MAX (A) and HIF proteins (B). MYC and Max dimerize via their bHLH-LZ domains, whereas HIF1α and HIF2α dimerize with HIF1β via their N-terminal bHLH domains. TAD, transactivation domain; bHLH, basic helix-loop-helix; LZ, leucine zipper; PAS, Per-Arnt-Sim homology; ODDD, oxygen-dependent degradation domain.
