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Models for the interplay between MYC and HIF. (A) HIF1α inhibits MYC activity under hypoxia. (B) HIF2α promotes MYC activity by stabilizing MYC-MAX complex. (C) MYC, when overexpressed, increases HIF levels and activity. (D) MYC also directly promotes HIF2α expression. (E) In cancer cells when MYC levels are high, MYC collaborates with HIFs to induce metabolic rewiring, tumor angiogenesis and CSC renewal, thereby promoting tumor cell growth and progression.
