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. 2020 Nov 12;2020:8864100. doi: 10.1155/2020/8864100

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Copyright © 2020 Siming Fu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Knockdown of Mc1r expression abolished the effects of NDP-MSH on oxidative stress and neuronal apoptosis following ICH. (a) The changes in the expression levels of MDA, CAT, and SOD in the perihematomal brain tissue after the administration of Mc1r siRNA. Representative Western blot images (b) and quantitative analyses of Mc1r (c), p-PI3K/PI3K (d), p-AKT/AKT (e), p-Nrf2/Nrf2 (f), Bcl-2 (g), and cleaved caspase 3 (h). n = 6 per group. ^#p < 0.05 vs. sham; ^∗p < 0.05 vs. ICH; ^@p < 0.05 vs. ICH + NDP-MSH + Scr siRNA. Scr siRNA: scrambled siRNA.