Figure 12.

Acute treatment with MK-801 (5 mg/kg) significantly impaired the 5 × TBS LTP response compared to controls. (a) Collective input/output curves between stimulation voltage and fEPSP slope overlap, showing no significant difference in basal synaptic excitability. (b) When compared to vehicle-treated subjects (black, n = 10), acute treatment with MK-801 (red, n = 7) significantly reduced the 5 × TBS LTP response throughout the whole 2-hour posttetanisation. Values represent means ± 95%confidenceintervals. Outsets above LTP curves represent average waveform field potentials during 30 min baseline prior to tetanisation and 0-30 min and 90-120 min posttetanisation. Horizontal bar: 1 mV; vertical bar: 5 ms. (c) PTP, STP, and LTP responses are presented as means ± 95%confidenceinterval; ^∗∗pvalue < 0.01 and ^∗∗∗pvalue < 0.001.