Figure 9.

Donepezil (1 mg/kg) significantly enhanced 5 × TBS LTP response when compared to control, saline-treated subjects. (a) Collective input/output curves of stimulation voltage and fEPSP slope overlap and show no significant difference in basal synaptic excitability prior to treatment with donepezil. However, the average response between 9 and 10 V showed a slightly lower response than control subjects in donepezil-treated subjects. (b) Basal fEPSPs were not affected; however, the LTP response of donepezil-treated subjects (green, n = 5) was significantly greater than control, saline-treated subjects (black, n = 10). Values represent mean ± 95%confidenceintervals. Outsets above LTP curves represent average waveform field potentials during 30 min baseline prior to tetanisation and 0-30 min and 90-120 min posttetanisation. Horizontal bar: 1 mV; vertical bar: 5 ms. (c) PTP, STP, and LTP responses are presented as means ± 95%confidenceintervals; ^∗∗pvalue < 0.01 and ^∗∗∗pvalue < 0.001).