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. Author manuscript; available in PMC: 2021 Jan 9.
Published in final edited form as: J Med Chem. 2019 Dec 27;63(1):433–439. doi: 10.1021/acs.jmedchem.9b01465

Figure 4.

Figure 4.

Concentration effect curves of mitragynine and 7-hydroxymitragynine at MOP (top left), DOP (middle left), and KOP (bottom left). Concentration % inhibition of control agonist effect curves of mitragynine and 7-hydroxymitragynine at MOP (top right), DOP (middle right), and KOP (bottom right). The EC50 of 7-hydroxymitragynine, speciociliatine, and mitragynine at MOP were determined as 7.6, 39.2, and 307.5 nM, respectively. The KB of 7-hydroxymitragynine at DOP and KOP were determined as 550.2 and 115.0 nM, respectively. The KB of mitragynine at MOP was determined as 179.2 nM.