FIG 3.

SH substitutions observed in seven sequenced MuV strains bearing hypervariable SH genes, relative to MuVi/Iowa.USA/00.06. Strains were geographically and temporally similar to MuVi/Hawaii.USA/44.17/12, the source of noncanonical SH₂ in Fig. 2B. All sequenced isolates shared the same substitutions in this region of the MuV genome. Substitutions were classified as synonymous or coding (amino acid substitution is noted); U-to-C substitutions are noted by color. For instances where multiple substitutions contribute to the coding result at a single codon, they were considered separately for all reported calculations.