TABLE 1.

Improving Pediatric Sepsis Outcomes Sepsis Definition

IPSO Sepsis
Stand-alone diagnostic criteria (presence of any of the following):
Severe sepsis, septic shock ICD-10 codes (R65.20, R65.21)
Severe sepsis order set
Positive huddle (bedside diagnosis, locally defined) of sepsis
Treatment criteria	Culture criterion	Additional criterion (any one of the following) within 24 hr of treatment
IV antibiotics and within 6 hr	Blood culture within 72 hr of treatment	Sepsis screen + (locally defined) ICU admission Lactate measured
Two boluses OR (bolus and vasoactive agent)		Vasoactive administered Other sepsis ICD-10 codes Infectious disease order set (locally defined, included order sets such as pneumonia or fever/neutropenia order sets)
IPSO Critical Sepsis: IPSO Sepsis criteria AND IV antibiotic AND ([three boluses within 6 hr] OR [bolus within 6hr and vasoactive agent within 24 hr])

ICD-10 = International Classification of Diseases, 10th Revision, IPSO = Improving Pediatric Sepsis Outcomes.

Patients meeting any stand-alone criteria or who had treatment and blood culture and at least one additional criterion had IPSO Sepsis. IPSO Critical Sepsis patients met this definition, including meeting treatment criteria, and additionally received a third bolus within 6 hr or vasoactive agent within 24 hr of meeting treatment criteria.