TABLE 3.
Study Population
| Percentages for These Columns Calculated From Cases in Which the Variable Was Reported, n (%) |
||||
|---|---|---|---|---|
| Population Characteristic | Hospitals Reporting Variable, n | Cases in Which This Variable Was Reported, n (%) | IPSO Sepsis | IPSO Critical Sepsis |
| Total | 40 | 23,976 (100.0) | 23,976 (100.0) | 8,565 (35.7) |
| Patient characteristics | ||||
| Age, yr, median (IQR) | 38 | 23,173 (96.7) | 5.9 (1.5–13.3) | 7.1 (1.9–14.1) |
| < 18 yr | 38 | 22,793 (95.1) | 21,175 (92.9) | 7,585 (92.2) |
| Medically complex | 40 | 23,976 (100.0) | 13,520 (56.4) | 5,607 (65.5) |
| Indwelling central venous catheter present on arrival | 34 | 20,357 (84.9) | 4,135 (20.3) | 2,269 (29.8) |
| Immunosuppressed or immunocompromised | 40 | 23,976 (100) | 10,316 (43.0) | 3,986 (46.5) |
| Chronically ventilated | 34 | 20,234 (84.4) | 2,352 (11.6) | 909 (12.1) |
| Transferred from outside hospital | 36 | 20,942 (87.3) | 2,621 (12.5) | 898 (11.4) |
| Treatment characteristics | ||||
| Sepsis episode starting location | 40 | 22,869 (95.4) | 22,869 (95.4) | 8,293 (96.8) |
| Emergency department | 16,024 (70.1) | 5,958 (71.8) | ||
| ICU | 3,761 (16.4) | 1,497 (18.0) | ||
| General inpatient floor | 2,135 (9.3) | 620 (7.5) | ||
| Hematology/oncology | 606 (2.6) | 156 (1.9) | ||
| Other | 343 (1.5) | 62 (0.8) | ||
| Total bolus volume in 6 hr surrounding time zero, mL/kg, median (IQR) | 38 | 22,391 (93.4) | 40.0 (20.0–46.0) | 58.8 (39.6–60.0) |
| Vasoactive agent during hospitalization | 36 | 21,829 (91.0) | 4,307 (19.7) | 3,065 (38.6) |
| Vasoactive days in patients requiring vasoactive, median (IQR) | 36 | 4,257 (98.8) | 2.0 (1.0–4.0) | 2.0 (1.0–4.0) |
| New positive-pressure ventilation | 30 | 13,083 (54.6) | 3,450 (26.4) | 1,529 (32.1) |
| Ventilation days in patients requiring ventilation, median (IQR) | 30 | 3,450 (100.0) | 5.0 (3.0–10.0) | 5.0 (3.0–10.0) |
| ICU admission | 38 | 22,430 (93.6) | 13,644 (60.8) | 6,115 (73.6) |
| ICU days associated with sepsis episode in patients with ICU admission, median (IQR) | 38 | 13,637 (99.9) | 4.0 (2.0–10.0) | 5.0 (2.0–10.0) |
| Hospital days per sepsis episode (capped at 31), median (IQR) | 39 | 23,507 (98.0) | 6.0 (3.0–13.0) | 7.0 (4.0–15.0) |
| Extracorporeal membrane oxygenation | 36 | 21,258 (88.7) | 289 (1.4) | 162 (2.1) |
| Laboratory data | ||||
| Blood culture positive | 36 | 20,860 (87.0) | 2,612 (12.5) | 1,066 (14.3) |
| Lactate, mmol/L, median (IQR) | 23 | 8,062 (33.6) | 1.9 (1.3–3.1) | 2.2 (1.3–3.6) |
| Outcomes | ||||
| Hypotension in first 24 hr of sepsis event | 36 | 21,532 (89.8) | 10,597 (49.2) | 4,771 (61.1) |
| Organ dysfunction present | 28 | 12,102 (50.5) | 5,773 (47.7) | 2,612 (58.0) |
| Sepsis-specific 30-d in-hospital mortality | 40 | 23,976 (100.0) | 597 (2.5) | 318 (3.7) |
| Sepsis-specific 30-d in-hospital mortality in medically complex patients | 40 | 13,520 | 483 (3.6) | 269 (4.8) |
| Sepsis-specific 30-d in-hospital mortality in nonmedically complex patients | 40 | 10,456 | 114 (1.1) | 49 (1.7) |
| All-cause 30-d in-hospital mortality | 40 | 23,976 (100.0) | 958 (4.0) | 541 (6.3) |
| All-cause 30-d in-hospital mortality in medically complex patients | 40 | 13,520 | 751 (5.6) | 439 (7.8) |
| All-cause 30-d in-hospital mortality in nonmedically complex patients | 40 | 10,456 | 207 (2.0) | 102 (3.4) |
IPSO = Improving Pediatric Sepsis Outcomes, IQR = interquartile range.
IPSO Critical Sepsis is a subset of IPSO Sepsis patients.