Table 3.
Univariate and multivariate Cox proportional analysis for the platinum-free interval
| Variable | No. | Univariate analysis |
Multivariate analysis |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Model 1a) |
Model 2b) |
|||||||||
| HR | 95% CI | P-value | HR | 95% CI | P-value | HR | 95% CI | P-value | ||
| Group A vs. group B | 222 | 0.816 | 0.558–1.192 | 0.292 | - | - | ||||
| FIGO stage | 222 | - | ||||||||
| I | ||||||||||
| II/III/IV | 17.041 | 6.926–41.929 | <0.001 | 13.386 | 5.065–35.381 | <0.001 | ||||
| Histology | 222 | - | ||||||||
| High-grade serous | ||||||||||
| Others | 3.527 | 2.248–5.535 | <0.001 | 1.050 | 0.632–1.743 | 0.851 | ||||
| Cytoreduction | 222 | - | ||||||||
| R0 | ||||||||||
| R1/2 | 3.977 | 2.686–5.886 | <0.001 | 2.111 | 1.415–3.151 | <0.001 | ||||
| Age (per 1) | 222 | 1.022 | 1.005–1.038 | 0.009 | - | 1.004 | 0.987–1.021 | 0.674 | ||
| WBC (per 1,000) | 222 | 1.016 | 0.956–1.079 | 0.613 | - | - | ||||
| Neutrophil (per 1,000) | 219 | 1.021 | 0.958–1.088 | 0.517 | - | - | ||||
| Lymphocyte (per 1,000) | 219 | 0.905 | 0.647–1.264 | 0.557 | - | - | ||||
| NLR (per 1) | 219 | 1.008 | 0.968–1.050 | 0.698 | − | - | ||||
| Platelet (per 1) | 222 | 1.002 | 0.996–1.008 | 0.498 | - | - | ||||
| PLR (per 1) | 219 | 1.000 | 1.000–1.001 | 0.158 | - | - | ||||
| CRP (per 1) | 222 | 1.006 | 0.975–1.039 | 0.705 | - | - | ||||
| LDH (per 1) | 222 | 1.001 | 1.000–1.002 | 0.019 | 1.001 | 1.000–1.002 | 0.019 | 1.000 | 0.998–1.001 | |
| Glucose (per 1) | 221 | 0.994 | 0.986–1.003 | 0.223 | - | - | ||||
| TC (per 1) | 186 | 0.998 | 0.993–1.002 | 0.349 | - | - | ||||
| TG (per 1) | 126 | 1.000 | 0.996–1.004 | 0.912 | - | - | ||||
| HDL (per 1) | 120 | 0.999 | 0.986–1.012 | 0.835 | - | - | ||||
| LDL (per 1) | 124 | 0.999 | 0.991–1.006 | 0.718 | - | - | ||||
| CA125 (per 1) | 219 | 1.000 | 1.000–1.000 | 0.004 | - | - | ||||
| Log CA125 (per 1) | 219 | 1.817 | 1.435–2.301 | <0.001 | - | - | ||||
Bold words represent statistical significance.
HR, hazard ratio; CI, confidence ratio; FIGO, International Federation of Gynecology and Obstetrics; WBC, white blood cell count; NLR, neutrophil to lymphocyte ratio; PLR, platelet to lymphocyte rate; CRP, C-reactive protein; LDH, lactate dehydrogenase; TC, total cholesterol; TG, triglyceride; HDL, high-density lipoprotein; LDL, low-density lipoprotein; CA125, cancer antigen 125.
a)
Adjusted for blood data;
b)
Adjusted for blood data and clinical characteristics (group, age, FIGO stage, histological type, and cytoreduction outcome).