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An NR2C/NR2D NMDA receptor antagonist suppressed tremor in Aspa/Hcn1 double-knockout rats. The total duration (left) and intensity (right) of body tremor in Aspaem34Kyo/Hcn1em1Kyo double-knockout rats given Ro 25-6981 (A) or cis-PPDA (B). cis-PPDA, an antagonist of NMDA receptors containing the NR2C and NR2D subunits, significantly suppressed both the duration and intensity of tremor throughout the observation period (60 min). *; P<0.05, **; P<0.001.
