Table 3.

Differences in MRI-synovial inflammatory biomarkers between the overweight and obese groups compared to the normal weight group (All p-values were statistically significant except for size of IPFP abnormality in the obese vs. normal weight group)

MRI-Inflammatory markers	Normal weight	Overweight			Obese			Overall P-valuea,b
	Mean ± SD	Mean ± SD	Difference compared to normal (95% CI)	P-valuea,b	Mean ± SD	Difference compared to normal (95% CI)	P-valuea,b
Effusion-synovitis
- ACLOAS method	0.37 ± 0.07	0.64 ± 0.07	0.27 (0.07 – 0.47)	0.01	0.71 ± 0.07	0.34 (0.14 – 0.53)	0.001	0.002
- MOAKS method	0.56 ± 0.07	0.94 ± 0.07	0.38 (0.19 – 0.58)	<0.001	1.05 ± 0.07	0.50 (0.30 – 0.69)	<0.001	<0.001
IPFP abnormality
- Highest SI	0.93 ± 0.09	1.35 ± 0.09	0.42 (0.18 – 0.66)	0.001	1.21 ± 0.09	0.28 (0.04 – 0.52)	0.02	0.002
- Size	0.76 ± 0.06	1.11 ± 0.06	0.35 (0.17 – 0.52)	<0.001	0.91 ± 0.06	0.14 (−0.03 – 0.31)	0.11	0.001
Synovial proliferation score
- Knee	0.82 ± 0.09	1.57 ± 0.09	0.75 (0.51 – 1.00)	<0.001	1.60 ± 0.09	0.78 (0.54 – 1.02)	<0.001	<0.001
- Popliteal cyst	0.30 ± 0.09	0.56 ± 0.09	0.26 (0.02 – 0.51)	0.04	0.61 ± 0.09	0.31 (0.06 – 0.56)	0.01	0.03

^aLinear regression analysis adjusted for age, gender and race

^bSignificant p-values are in bold (p-value < 0.05)

ACLOAS, Anterior Cruciate Ligament OsteoArthritis Score; MOAKS, MRI Osteoarthritis Knee Score; IPFP, InfraPatellar Fat Pad; SI, signal intensity