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Drug release profiles of NPs with regard to pH at PBA/DOX ratios of 2 and 4. (a) pH-dependent DOX release profiles of each NP incubated at pH 5.0 and pH 7.5. Amount of loaded DOX was regarded as 100%. (b) Morphology of each NP incubated at pH 5.0 and pH 7.5 for 2 h were observed by TEM with negative staining. Scale bar = 200 nm.
