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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Nat Microbiol. 2020 Sep 7;5(12):1542–1552. doi: 10.1038/s41564-020-0785-y

Fig. 3 |. Structure of the triplex and its interactions with the surrounding MCPs.

Fig. 3 |

a–c, Detailed structures of triplex Tb (a) and its components Tri2A (b) and Tri2B (c). d, Superposition of Tri2A and Tri2B shows constant trunk domains and conformational differences in their embracing arm domains. e,f, Density map (e) and models (f) of triplex Tb and its surrounding MCPs. A close-up view of the density map of triplex Tb with the tri-lobed density of its flexible Tri1 N-anchor (grey) is shown in the dashed box. g,h, Interactions of the triplex with its surrounding MCPs. The buttress arms of MCP P3, E1 and C5 consistently insert into and interact with triplex Tb mainly through the loop containing residues 1176–1192. The interacting regions between the triplex and MCPs in g are highlighted with magnified views in the dashed boxes (h). h, Bottom right: the superimposed interacting regions with buttress arms of MCPs P3, E1 and C5 in the same orientation.