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. Author manuscript; available in PMC: 2021 Feb 24.
Published in final edited form as: Nat Microbiol. 2020 Aug 24;5(12):1490–1503. doi: 10.1038/s41564-020-0778-x

Extended Data Fig. 1. Enrichment of IFIT2 and IFIT3 over sequential influenza virus selections.

Extended Data Fig. 1

a, Schematic for hit analysis and selection. b-c, Frequency distribution of sgRNAs present in the parental libraries and those following selection with WSN (b) or SC35M (c). d-f, sgRNA enrichment trajectories following (d) sequential IAV-G selections, (e) IAV-G followed by bona fide influenza virus (WSN) infection or (f) selection with SC35M-GFP. The abundance of each sgRNA targeting the indicated gene is shown. g, Overlap between top hits from each screen. A conservative cutoff of RRA<10−5 was used to define top hits.