FIGURE 4.

GSEP supplementation increases thromboxane mimetic-induced constriction of uterine arteries in eNOS^–/– mice. Aortas of eNOS^–/– mice (A), but not mesenteric (D) or uterine arteries (G), showed significantly higher constriction to U46619 compared with WT controls. Maternal GSEP supplementation did not affect constriction in response to U46619 of either aortas (B,C) or mesenteric arteries (E,F) in WT or eNOS^–/– mice. In uterine arteries, GSEP treatment had no effect on U46619-induced constriction in WT (H) but significantly increased vasoconstriction in eNOS^–/– mice (I). ^##P < 0.01 eNOS^–/– vs. WT; ****P < 0.0001 GSEP vs. H₂O. N = 6–11 dams per group.