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. 2020 Nov 6;8:565826. doi: 10.3389/fcell.2020.565826

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Copyright © 2020 Lee, Park, Kim, Lee, Koh and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of lumican on osteoblastogenesis are mediated by the simulation of ERK signal. (A) Western blot analysis to determine the activity of signals related to osteoblast differentiation after treatment with 10 nM lumican in MC3T3-E1 cells. (B,C) Murine preosteoblast MC3T3-E1 cells were pretreated with 20 μM PD98059 or 10 μM U0126, ERK inhibitors, followed by treatment with the indicated concentrations of lumican in the presence of 50 μg/mL ascorbic acid and 10 mM β-glycerophosphate. Runx2 and ALP activities were assessed after 5 and 7 days, respectively. Data are presented as mean ± SEM. *P < 0.05 vs. control; ^#P < 0.05 vs. lumican-treated group.