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. 2020 Nov 19;10:20142. doi: 10.1038/s41598-020-77180-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MDA-231 and HLF tumor spheroid-induced angiogenesis. (a) A schematic illustration of the experimental design. (b) A representative bright-field image of the HUVEC channel and tumor spheroids in the HLF-laden ECM within the microfluidic chip device. (c,d) Confocal images of MDA-231 and HLF tumor spheroid-induced angiogenesis at day 0 (c), day 2 (d), and day 6 (e). (f) An enlarged area of the tumor spheroid-vasculature interface that is highlighted in (e).