TABLE 2.
Nominally significant common variants between sLOAD and cognitively healthy individuals.
| Gene | Position | rs ID | Mutation regions | MAF (case/control) | P | Corrected P-value | OR | OR 95% CI |
| BIN1 | chr2:127839474 | rs11682128 | UTR5 | 0.225/0.171 | 0.011 | 0.000153* | 1.403 | 1.079–1.824 |
| BIN1 | chr2:127839534 | rs11690153 | UTR5 | 0.151/0.087 | 0.000 | 0.001795 | 1.861 | 1.335–2.595 |
| BIN1 | chr2:127864546 | rs11554586 | UTR5 | 0.134/0.087 | 0.004 | 0.001997 | 1.630 | 1.162–2.287 |
| BIN1 | chr2:127841945 | rs58402148 | UTR5 | 0.151/0.096 | 0.002 | 0.004478 | 1.675 | 1.212–2.316 |
| BIN1 | chr2:127839434 | rs4663093 | UTR5 | 0.163/0.217 | 0.008 | 0.022542 | 0.699 | 0.536–0.912 |
| PPP2CA | chr5:133561589 | rs3863186 | UTR5 | 0.484/0.425 | 0.024 | 0.053867 | 1.270 | 1.031–1.565 |
| PPP2R2A | chr8:26227640 | rs3808565 | Intronic | 0.444/0.380 | 0.014 | 0.05845 | 1.302 | 1.054–1.608 |
| NEP | chr3:154866453 | rs1436633 | Intronic | 0.173/0.235 | 0.004 | 0.069732 | 0.684 | 0.528–0.886 |
| NEP | chr3:154899943 | rs1126662 | UTR3 | 0.223/0.291 | 0.003 | 0.084561 | 0.699 | 0.551–0.887 |
| NEP | chr3:154898407 | rs701109 | UTR3 | 0.323/0.377 | 0.031 | 0.178405 | 0.788 | 0.634–0.979 |
| MMP9 | chr20:44640225 | rs17576 | Exonic | 0.242/0.293 | 0.030 | 0.261342 | 0.771 | 0.610–0.975 |
| NEP | chr3:154901205 | rs6665 | UTR3 | 0.245/0.303 | 0.013 | 0.414257 | 0.745 | 0.590–0.941 |
| NEP | chr3:154900690 | rs12765 | UTR3 | 0.237/0.293 | 0.016 | 0.530354 | 0.749 | 0.592–0.947 |
MAF, minor allele frequency; OR, odds ratio; CI, confidence interval. Corrected P-value, P-value after the adjustment of age, gender, and APOE ε4 status; UTR5, untranslated region 5; UTR3, untranslated region 3; sLOAD, sporadic late-onset Alzheimer’s disease. *Corrected P-value < 0.00051 (0.05/98) was considered as statistically significant.