TABLE 3.

Gene-based SKAT-O test.

Transcript ID	Position	Gene	Number of variants	P value	Corrected P value
NM_001397	chr1:21543823.21671981	ECE1	70	0.3996	0.1528
NM_033467	chr1:2522081.2564481	MMEL1	56	0.5486	0.3231
NM_001286126	chr1:220701525.220837799	MARK1	46	0.2011	0.2113
NM_139343	chr2:127805599.127864903	BIN1	54	0.0865	0.2066
NM_002093	chr3:119540800.119813264	GSK3B	70	0.8488	0.8357
NM_000902	chr3:154797436.154901518	NEP	60	0.0035	0.0232
NM_002715	chr5:133532148.133561950	PPP2CA	7	0.2398	0.2946
NM_004935	chr7:150750899.150755052	CDK5	15	0.8119	1
NM_002717	chr8:26149007.26230196	PPP2R2A	27	0.3782	0.2614
NM_001322795	chr10:94211441.94333852	IDE	55	0.2392	0.0729
NM_016147	chr11:73882108.73965748	PPME1	22	0.03766	0.2638
NM_012104	chr11:117156402.117186972	BACE1	18	0.4485	0.3147
NM_001134999	chr14:53323989.53417815	FERMT2	28	0.0192	0.0159
NM_006305	chr15:69070874.69113261	ANP32A	23	1	0.7828
NM_001032391	chr16:25123047.25189551	LCMT1	19	0.8202	0.9217
NM_000789	chr17:61554422.61575741	ACE	85	0.2817	0.2429
NM_006221	chr19:9945883.9960365	PIN1	15	0.2137	0.3725
NM_004994	chr20:44637547.44645200	MMP9	25	0.2139	0.3106
NM_138991	chr21:42539728.42654461	BACE2	84	0.2815	0.1322

P value, P value before correction; Corrected P-value, P-value after the adjustment of age, gender, and APOEε4 status; SKAT-O, optimized sequence kernel association test.

Corrected P-value < 0.0026 (0.05/19) was considered as statistically significant.