TABLE 4.

Pathway-based SKAT-O test.

Pathway	Genes	Number of variants	P	Corrected P value
Aβ degradation	NEP, IDE, MMP9, ACE, ECE1, MMEL1	351	0.054	0.021*
	IDE, MMP9, ACE, ECE1, MMEL1	291	0.170	0.071
Aβ generation	BACE1, BACE2	102	0.252	0.098
Tau kinase	GSK3B, CDK5, MARK1	131	0.641	0.710
Tau pathology	FERMT2, BIN1	82	0.009	0.031*
	BIN1	54	0.087	0.207
Tau phosphatase	PPME1, PPP2CA, PPP2R2A, PIN1, ANP32A, LCMT1	113	0.017	0.033*
	PPP2CA, PPP2R2A, PIN1, ANP32A, LCMT1	91	0.206	0.129

In the Aβ degradation, tau pathology, and tau phosphatase pathways, the driver genes are in bold. P value, P value before correction; Corrected P-value, P-value after the adjustment of age, gender, and APOE ε4 status; SKAT-O, optimized sequence kernel association test.

*Corrected P-value < 0.01 (0.05/5) was considered as statistically significant.