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(A) MG53 controls cytosolic calcium through interactions with Orai1, RyR1, TRPC3, TRPC4, CaM1, and SERCA. (B) MG53 aggregates around the mitochondria of skeletal muscle in the presence of reactive oxygen species. (C) MG53 promotes plasma membrane repair by facilitating vesicle translocation following injury. Golden spheres represent MG53. Created with BioRender.com.
