Table 2.
Physiological parameters, referred to the three EAdi-defined neuro-ventilatory drive classes
| “Low” class (EAdiPEAK < 5 μV) |
“Normal” class (EAdiPEAK 5–15 μV) |
“High” class (EAdiPEAK > 15 μV) |
|
|---|---|---|---|
| VT/PBW (ml/kg) | 7.2 [6.2–8.3] | 7.5 [6.3–9.2]* | 8.8 [6.9–9.5]* |
| RR (breaths/min) | 19.7 [15.0–28.9] | 19.1 [15.8–22.7]* | 15.6 [14.8–21.7]*# |
| PEEP (cmH2O) | 6.2 [5.2–9.9] | 7.2 [5.9–8.0] | 7.8 [6.7–12.1] |
| Pao,PEAK (cmH2O) | 17.5 [14.4–20.9] | 18.0 [16.8–18.7] | 19.3 [18.0–20.0]*# |
| Ti,MECH (s) | 0.97 [0.76–1.18] | 1.02 [0.86–1.17] | 1.01 [0.80–1.14]*# |
| Ti,NEUR (s) | 1.05 [0.81–1.27] | 1.17 [0.93–1.41] | 1.13 [0.83–1.38]*# |
| EAdiPEAK (μV) | 3.2 [2.1–4.1] | 8.0 [6.5–10.1] | 19.9 [17.2–28.5]*# |
| EAdiSLOPE ( μV/s) | 2.6 [1.9–3.7] | 6.4 [5.1–9.3]* | 21.1 [14.7–27.8]*# |
| PTPDI/b (cmH2O/s) | 2.2 [1.4–3.4] | 6.6 [3.8–9.3]* | 12.4 [8.0–17.3]*# |
| PTPDI/min (cmH2O/s/min) | 46 [29–76] | 110 [73–164]* | 213 [160–309]*# |
Data expressed as median and interquartile range [IQR]
EAdi = diaphragmatic electrical activity; VT = tidal volume; PBW = predicted body weight; RR = respiratory rate; PEEP = positive end expiratory pressure; Pao,PEAK = peak airway opening pressure; Ti,MECH = mechanical inspiratory time; Ti,NEUR = neural inspiratory time; EAdiPEAK = peak diaphragmatic electrical activity; EAdiSLOPE = slope from the beginning of inspiration to EAdiPEAK; PTPDI/b = inspiratory pressure–time product of the diaphragm, per breath; PTPDI/min = inspiratory pressure–time product of the diaphragm, per minute
*p < 0.05 compared to the “Low” EAdi class
#p < 0.05 compared to the “Normal” EAdi class