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. 2020 Sep 3;75(12):1112–1115. doi: 10.1136/thoraxjnl-2020-214656

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Supralethal influenza challenge in mice expressing T13B antibody via the rSIV.F/HN vector. Mice (n=5–6 per group) were dosed intranasally with rSIV.F/HN.hCEF.T13B at a dose of 1E7 TU (blue), 1e8 TU (red), 2.7e8 TU (magenta) or with 1e8 TU (black) of rSIV.F/HN.hCEF.GLux (Gaussia Luciferase) as mock control. (A–D) BALB/c mice were challenged with 10 or 100 median lethal dose (LD₅₀) of H1N1 A/PR/8/1934 (Cambridge). (E, F) DBA/2 mice were challenged with 10 LD₅₀ of reassortant pandemic H1N1 A/CA/7/2009-X179A. Body weight was measured daily for 14 days and mice were euthanised if weight loss declined ≥20% as depicted in the Kaplan-Meier survival curve (right column). SIV, simian immunodeficiency virus; TU, transducing units.