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. 2020 Sep 14;91(12):1329–1338. doi: 10.1136/jnnp-2020-323611

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Partial least squares-discriminant analysis (PLS-DA) analysis of amyotrophic lateral sclerosis (ALS) cases versus controls. (A) PLS-DA score plot of ALS cases (red) versus controls (blue); each dot represents an individual subject. (B) The variable importance in projection (VIP) score plot of the top 30 PLS-DA metabolites, which most significantly separate cases from controls. A total of 295 metabolites had VIP >1. Asterisks denote compounds that have not been confirmed against a standard, but whose identity the analytical platform is confident in.