Table 3.
Association between incident OA and risk of venous thromboembolism (sensitivity analysis)
| Knee OA (n=20 696) | Non-OA (n=81 137) | Hip OA (n=10 411) | Non-OA (n=41 594) | Hand OA (n=6329) | Non-OA (n=25 206) | |
| Venous thromboembolism | ||||||
| Events (n) | 327 | 834 | 201 | 393 | 57 | 211 |
| Mean follow-up (years) | 5.86 | 5.50 | 5.83 | 5.50 | 5.84 | 5.50 |
| Incidence rate, per 1000 person-years | 2.7 | 1.9 | 3.3 | 1.7 | 1.5 | 1.5 |
| RD (95% CI), per 1000 person-years | 0.8 (0.5 to 1.1) |
0.0 (reference) |
1.6 (1.1 to 2.1) |
0.0 (reference) |
0.0 (−0.5 to 0.5) |
0.0 (reference) |
| Age, sex, BMI and entry year-matched HR (95% CI) | 1.47 (1.31 to 1.66) |
1.00 (reference) |
1.90 (1.63 to 2.21) |
1.00 (reference) |
0.97 (0.74 to 1.28) |
1.00 (reference) |
| Multivariable-adjusted HR (95% CI)* | 1.45 (1.29 to 1.64) |
1.00 (reference) |
1.87 (1.60 to 2.20) |
1.00 (reference) |
0.91 (0.70 to 1.20) |
1.00 (reference) |
| Pulmonary embolism | ||||||
| Events (n) | 172 | 390 | 101 | 196 | 25 | 100 |
| Mean follow-up (years) | 5.89 | 5.52 | 5.88 | 5.52 | 5.86 | 5.51 |
| Incidence rate, per 1000 person-years | 1.4 | 0.9 | 1.7 | 0.9 | 0.7 | 0.7 |
| RD (95% CI), per 1000 person-years | 0.5 (0.3 to 0.7) |
0.0 (reference) |
0.8 (0.5 to 1.1) |
0.0 (reference) |
0.0 (−0.3 to 0.3) |
0.0 (reference) |
| Age, sex, BMI and entry year-matched HR (95% CI) | 1.71 (1.45 to 2.01) |
1.00 (reference) |
1.94 (1.57 to 2.41) |
1.00 (reference) |
0.89 (0.59 to 1.35) |
1.00 (reference) |
| Multivariable-adjusted HR (95% CI)* | 1.73 (1.47 to 2.05) |
1.00 (reference) |
2.08 (1.65 to 2.63) |
1.00 (reference) |
0.87 (0.56 to 1.34) |
1.00 (reference) |
| Deep vein thrombosis | ||||||
| Events (n) | 174 | 491 | 115 | 219 | 36 | 117 |
| Mean follow-up (years) | 5.89 | 5.51 | 5.86 | 5.51 | 5.85 | 5.51 |
| Incidence rate, per 1000 person-years | 1.4 | 1.1 | 1.9 | 1.0 | 1.0 | 0.8 |
| RD (95% CI), per 1000 person-years | 0.3 (0.1 to 0.5) |
0.0 (reference) |
0.9 (0.5 to 1.3) |
0.0 (reference) |
0.2 (−0.2 to 0.6) |
0.0 (reference) |
| Age, sex, BMI and entry year-matched HR (95% CI) | 1.31 (1.12 to 1.53) |
1.00 (reference) |
1.93 (1.57 to 2.38) |
1.00 (reference) |
1.15 (0.82 to 1.61) |
1.00 (reference) |
| Multivariable-adjusted HR (95% CI)* | 1.28 (1.09 to 1.50) |
1.00 (reference) |
1.87 (1.51 to 2.31) |
1.00 (reference) |
1.07 (0.76 to 1.52) |
1.00 (reference) |
*In addition to the matching variables, multivariable models were adjusted for region, smoking status (ie, non-smokers, ex-smokers and current smokers), alcohol drinking (ie, non-drinkers, ex-drinkers and current drinkers), number of GP visits, comorbidities, medication use, trauma, fracture, surgery and hospitalisation prior to the index date.
BMI, body mass index; n, number; OA, osteoarthritis; RD, rate difference.