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. 2020 Nov 6;7:583943. doi: 10.3389/fmed.2020.583943

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Copyright © 2020 Pang, Sun, Shao, Cai, Bao, Wang, Li, Jing, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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After AAV injection, the expression of RAGE in liver and aorta changed (A) and (B) Immunohistochemistry shows the expression of RAGE (×400). (C–F) Detection of IL-1β, IL-6, TNF-α, CRP mRNA expression levels in liver and aorta by PCR (G,H) Percentage of RAGE positive immunohistochemical staining area. The proportion of the positive area to the total Liver area was calculated by ImageJ. *P < 0.05, compared with normal control group; ^#P < 0.05, compared with model group;^&P < 0.05, compared with CML group.