TABLE 4.

SNP-array results of 1784 samples with advanced maternal age (≥35).

Age	Number	Normal	Aneuploidy	LOH	CNV	CNV a
						P	LP	VOUS	LB
35	299 (16.8%)	270 (90.3%)	6 (2.0%)	2 (0.7%)	21 (7.0%)	4(1.3%)	1	10	6
36	379 (21.2%)	342 (90.2%)	10 (2.6%)	1 (0.3%)	26 (6.9%)	7(1.8%)	2	13	4
37	344 (19.3%)	303 (88.1%)	18 (5.2%)	2 (0.6%)	21 (6.1%)	5(1.5%)	0	8	8
38	230 (12.9%)	211 (91.7%)	6 (2.6%)	0 (0.0%)	13 (5.7%)	1(0.4%)	2	6	4
39	170 (9.5%)	142 (83.5%)	11 (6.5%)	2 (1.2%)	15 (8.8%)	3(1.8%)	1	6	5
40	132 (7.4%)	118 (89.4%)	4 (3.0%)	1 (0.8%)	9 (6.8%)	3(2.2%)	0	2	4
≥41	230 (12.9%)	205 (89.1%)	19 (8.3%)	2 (0.9%)	4 (1.7%)	0(0.0%)	0	3	1
Total	1784 [100]	1591 (89.2%)	74 (4.1%)	10 (0.6%)	109 (6.1%)	23(1.3%)	6	48	32

^aCNVs were classified into four groups according to interpretation: P, pathogenic; LP, likely pathogenic; VOUS, variation of uncertain significance; LB, likely benign. For cases with 2 CNVs including a pathogenic CNV and a VOUS CNV were listed in the P group.