Table 1.
Overview of the results of the four fungal diagnostic methods showing positive results, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).
| Diagnostic method | Positive results (%) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|
| KOH examination* | 35.09 | 83.33 | 100.00 | 100.00 | 89.19 |
| Fungal culture* | 19.30 | 45.83 | 100.00 | 100.00 | 71.74 |
| Histology* | 19.30 | 45.83 | 100.00 | 100.00 | 71.74 |
| Ex vivo CLSM | 63.16 | 91.67 | 57.58 | 61.11 | 90.48 |
*
In the study design these methods were defined as the combined gold standard with a consequence of showing 100% in specificity and PPV.
CLSM, confocal laser scanning microscopy; PPV, positive predictive value; NPV, negative predictive value.