Table 2.
Select mutations to genes associated with the homologous recombination DNA repair pathway are associated with poor survival in a pan cancer cohort (N = 33,633).
| Gene | Median months survival without mutation | Median months survival with mutation | P value |
|---|---|---|---|
| All genes | 105.91 | 60.50 | P < 0.0001 |
| ATM | 99.97 | 71.68 | P = 1.610 × 10–4 |
| BARD1 | 98.80 | 53.77 | P = 1.34 × 10–4 |
| BRCA1 | 99.00 | 82.63 | P = 0.203 |
| BRAC2 | 99.90 | 73.16 | P = 1.577 × 10–4 |
| BRCA1/2 | 100.62 | 73.16 | P = 1.792 × 10–5 |
| BRIP1 | 98.80 | 80.00 | P = 0.139 |
| CHEK2 | 86.37 | 98.5 | P = 0.872 |
| CDK12 | 99.40 | 53.15 | P = 5.195 × 10–3 |
| DMC1 | 98.77 | 50.3 | P = 5.579 × 10–3 |
| FAAP20 | 98.70 | 37.71 | P = 0.0136 |
| FAN1 | 98.70 | 76.97 | P = 0.833 |
| FANCD2 | 98.70 | 74.00 | P = 0.606 |
| FANCE | 98.32 | – | – |
| FANCL | 98.50 | 109/00 | P = 0.885 |
| FANCM | 98.83 | 57.59 | P = 0.0567 |
| PALB2 | 98.90 | 50.72 | P = 0.0114 |
| POLQ | 99.53 | 63.50 | P = 1.141 × 10–3 |
| RAD51 | 98.50 | 72.01 | P = 0.809 |
| RAD51B | 98.370 | 156.9 | P = 0.549 |
| RAD51C | 98.70 | 42.00 | P = 0.137 |
| RAD51D | 98.70 | 75.43 | P = 0.121 |
| RAD54L | 98.50 | 77.00 | P = 0.367 |
| XRCC3 | 98.37 | 109.00 | P = 0.295 |