Table 7.
Mutation frequencies of genes associated with the homologous recombination DNA repair pathway in the TCGA Head & Neck squamous cell carcinoma cohort (N = 512).
| Gene | Observed mutations head and neck squamous cell carcinoma (N = 512) | Mutation frequency (%) |
|---|---|---|
| ATM | 15 | 2.930 |
| BARD1 | 9 | 1.758 |
| BRCA1 | 11 | 2.148 |
| BRAC2 | 23 | 4.492 |
| BRCA1/2 | 34 | 6.641 |
| BRIP1 | 13 | 2.539 |
| CHEK2 | 21 | 4.102 |
| CDK12 | 7 | 1.367 |
| DMC1 | 1 | 0.195 |
| FAAP20 | – | – |
| FAN1 | 5 | 0.977 |
| FANCD2 | 10 | 1.953 |
| FANCE | – | – |
| FANCL | 4 | 0.781 |
| FANCM | 10 | 1.953 |
| PALB2 | 7 | 1.367 |
| POLQ | 22 | 4.2975 |
| RAD51 | 1 | 0.195 |
| RAD51B | 1 | 0.195 |
| RAD51C | 3 | 0.586 |
| RAD51D | 2 | 0.391 |
| RAD54L | 5 | 0.977 |
| XRCC3 | – | – |
| Any HR mutation | 139 | 27.148 |