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. 2020 Nov 19;6:32. doi: 10.1038/s41537-020-00122-3

Table 4.

Proportion of concomitant medication use by antipsychotic drug.

Amisulpride Aripiprazole Clozapine Haloperidol Olanzapine Paliperidone Quetiapine Risperidone Ziprasidone
Concomitant medication (N = 213) (N = 556) (N = 336) (N = 83) (N = 441) (N = 393) (N = 355) (N = 730) (N = 150)
Mood stabilizers, n (%)
 Carbamazepine 1 (0.5) 2 (0.4) 1 (0.3) 0 (0) 1 (0.2) 2 (0.5) 6 (1.7) 6 (0.8) 2 (1.3)
 Lamotrigine 15 (7.0) 29 (5.2) 27 (8.0) 5 (6.0) 17 (3.9) 13 (3.3) 19 (5.4) 22 (3.0) 6 (4.0)
 Lithium 9 (4.2) 10 (1.8) 10 (3.0) 6 (7.2) 14 (3.2) 10 (2.5) 15 (4.2) 16 (2.2) 3 (2.0)
 Topiramate 2 (0.9) 19 (3.4) 31 (9.2) 0 (0) 16 (3.6) 12 (3.1) 16 (4.5) 16 (2.2) 7 (4.7)
 Valproate 25 (11.7) 58 (10.4) 67 (19.9) 11 (13.3) 43 (9.8) 41 (10.4) 45 (12.7) 84 (11.5) 11 (7.3)
Antidepressants, n (%)
 Bupropion 8 (3.8) 11 (2.0) 4 (1.2) 0 (0) 8 (1.8) 11 (2.8) 8 (2.3) 14 (1.9) 4 (2.7)
 Clomipramine 6 (2.8) 3 (0.5) 10 (3.0) 4 (4.8) 4 (0.9) 1 (0.3) 4 (1.1) 7 (1.0) 0 (0)
 Duloxetine 4 (1.9) 5 (0.9) 2 (0.6) 0 (0) 5 (1.1) 7 (1.8) 2 (0.6) 3 (0.4) 1 (0.7)
 Escitalopram 43 (20.2) 86 (15.5) 56 (16.7) 7 (8.4) 59 (13.4) 55 (14.0) 40 (11.3) 87 (11.9) 22 (14.7)
 Fluoxetine 17 (8.0) 41 (7.4) 35 (10.4) 6 (7.2) 37 (8.4) 25 (6.4) 23 (6.5) 48 (6.6) 15 (10.0)
 Fluvoxamine 5 (2.3) 2 (0.4) 6 (1.8) 0 (0) 3 (0.7) 3 (0.8) 2 (0.6) 13 (1.8) 2 (1.3)
 Mirtazapine 5 (2.3) 6 (1.1) 1 (0.3) 0 (0) 5 (1.1) 4 (1.0) 8 (2.3) 6 (0.8) 2 (1.3)
 Paroxetine 6 (2.8) 10 (1.8) 5 (1.5) 0 (0) 7 (1.6) 3 (0.8) 7 (2.0) 17 (2.3) 1 (0.7)
 Sertraline 35 (16.4) 65 (11.7) 103 (30.7) 14 (16.9) 42 (9.5) 61 (15.5) 34 (9.6) 77 (10.5) 22 (14.7)
 Venlafaxine 3 (1.4) 2 (0.4) 1 (0.3) 0 (0) 0 (0) 3 0.8) 3 (0.8) 4 (0.5) 0 (0)
Anxiolytics/Hypnotics, n (%)
 Alprazolam 21 (9.9) 35 (6.3) 26 (7.7) 4 (4.8) 21 (4.8) 30 (7.6) 23 (6.5) 48 (6.6) 10 (6.7)
 Clonazepam 58 (27.2) 122 (21.9) 72 (21.4) 11 (13.3) 100 (22.7) 82 (20.9) 95 (26.8) 142 (19.5) 29 (19.3)
 Diazepam 15 (7.0) 25 (4.5) 19 (5.7) 13 (15.7) 18 (4.1) 18 (4.6) 21 (5.9) 45 (6.2) 5 (3.3)
 Lorazepam 114 (53.5) 326 (58.6) 211 (62.8) 42 (50.6) 267 (60.5) 213 (54.2) 205 (57.7) 425 (58.2) 86 (57.3)
 Trazodone 7 (3.3) 6 (1.1) 0 (0) 2 (2.4) 8 (1.8) 12 (3.1) 13 (3.7) 12 (1.6) 2 (1.3)
 Zolpidem 29 (13.6) 37 (6.7) 23 (6.8) 4 (4.8) 36 (8.2) 43 (10.9) 49 (13.8) 49 (6.7) 14 (9.3)
Anticholinergics/Propranolol, n (%)
 Benztropine 70 (32.9) 136 (24.5) 96 (28.6) 44 (53.0) 106 (24.0) 128 (32.6) 85 (23.9) 271 (37.1) 38 (25.3)
 Trihexyphenidyl 38 (17.8) 102 (18.3) 62 (18.5) 23 (27.7) 87 (19.7) 81 (20.6) 63 (17.7) 154 (21.1) 28 (18.7)
 Propranolol 70 (32.9) 195 (35.1) 139 (41.4) 25 (30.1) 137 (31.1) 133 (33.8) 106 (29.9) 193 (26.4) 47 (31.3)