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. 2020 Nov 19;10:20166. doi: 10.1038/s41598-020-76754-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Left panel is speed of sound (inverted grayscale) fused with reflection image (axial). Middle panel is MR image (axial). A direct correspondence is seen between the vastus lateralis and vastus medialis muscle groups between the two images. The Sartorius, semimembranosus, biceps femoris muscles are seen to correspond in both images. The gray-scale is inverted for the SOS fused image on the left so the muscle groups appear dark in this image. The QTUS shows more detail than other color schemes due to highlighting of connective tissue. A close up of a fused QTUS knee image (axial) on the right shows also a cross-section (yellow bar), showing the thickness of connective tissue is 0.6 mm full-width half max (FWHM). Notice also the complete separation between dermis, epidermis, hypodermis in the right panel closeup. (blue arrow).