Figure 10.

Schematic showing the orthogonal regulation of DNA nanodevice for programmed tumor cell recognition and treatment. (A) The orthogonal photoactivation behavior of the DNA nanodevice in response to two NIR light of different wavelengths. (B) Sequential activation of the nanodevice with orthogonal UCL for programmed tumor recognition and PDT. UCL spectra of the core-multishell UCNPs upon excitation of 808 (C) and 980 nm (D). (E) Schematic illustration of combining PT-UN(+) with α-PD-L1 therapy to inhibit tumor growth at both primary and distant sites. Tumor growth curves of primary tumors (F) and distant tumors (G) of bilateral tumor-bearing mice with different treatments. Data are means ± SD (n = 5). Copyright 2020, American Association for the Advancement of Science (Di et al., 2020). **P < 0.01, ***P < 0.001.