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. 2020 Nov 6;8:596658. doi: 10.3389/fchem.2020.596658

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Copyright © 2020 Chen, Xie, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Schematic illustration of the structure of TPZ/UCSs and their application to tumor treatment through a combination of NIR light-triggered PDT and hypoxia-activated chemotherapy with immunotherapy. (B) Schematic illustration of NIR light-triggered combinational therapy. (C) Growth curves of primary tumors (left) and distant tumors (right) in CT26 tumor-bearing mice after different treatments. Photographs of primary tumors and distant tumors collected from mice 14 days after treatments: (1) PBS, (2) TPZ/UCSs(–), (3) TPZ/ UCSs(+), (4) α-PD-L1, (5) TPZ/UCSs(–) + α-PD-L1, and (6) TPZ/UCSs(+) + α-PD-L1. Percentage of tumor-infiltrating (D) CD4⁺ T cells, (E) CD8⁺ T cells in total tumor cells. Data are means ± SD; N = 4. *P < 0.05, **P < 0.01. Copyright 2020, American Chemical Society (Shao et al., 2020).