TABLE 2.
Statistical analysis of potential metabolic biomarkers.
| Id | Name | Formula | Retention time (min) | Molecular | VIP | Fold change | p | AUC |
|---|---|---|---|---|---|---|---|---|
| 1 | Glutamic acid | C5H9NO4 | 0.992 | 147.053 | 2.554 | 0.551 | 1.10E−22 | 0.916 |
| 2 | LysoPE (18:0) | C23H48NO7P | 8.749 | 481.317 | 8.845 | 0.826 | 3.47E−22 | 0.893 |
| 3 | Taurine | C2H7NO3S | 0.970 | 125.014 | 1.844 | 0.652 | 5.98E−15 | 0.850 |
| 4 | LysoPC (17:0) | C25H52NO7P | 9.199 | 509.347 | 1.424 | 0.676 | 1.22E−13 | 0.847 |
| 5 | Sphingosine 1-phosphate | C18H38NO5P | 7.786 | 379.248 | 1.090 | 0.788 | 1.21E−14 | 0.837 |
| 6 | 11,12-EpETrE | C20H32O3 | 8.729 | 320.235 | 2.269 | 0.442 | 2.96E−12 | 0.834 |
| 7 | Eicosapentaenoic acid | C20H30O2 | 8.727 | 302.224 | 1.296 | 0.467 | 1.77E−11 | 0.819 |
| 8 | Pyroglutamic acid | C5H7NO3 | 1.253 | 129.042 | 1.659 | 0.778 | 1.19E−11 | 0.815 |
| 9 | LysoPC (P-16:0) | C24H50NO6P | 8.973 | 479.336 | 1.150 | 0.757 | 1.05E−11 | 0.798 |
| 10 | Acetyl-l-carnitine | C9H17NO4 | 1.247 | 203.115 | 1.604 | 0.666 | 4.06E−09 | 0.773 |
| 11 | Leucine/Isoleucine/Norleucine | C6H13NO2 | 1.463 | 131.094 | 6.792 | 0.846 | 5.91E−07 | 0.730 |
| 12 | 5-Aminopentanamide | C5H12N2O | 3.706 | 116.095 | 1.580 | 1.410 | 2.25E−04 | 0.719 |
| 13 | LysoPC (20:4) | C28H50NO7P | 8.336 | 543.331 | 4.907 | 1.278 | 7.46E−06 | 0.704 |
| 14 | LysoPC (16:1) | C24H48NO7P | 8.096 | 493.316 | 1.821 | 0.808 | 8.20E−06 | 0.698 |
| 15 | LysoPE (20:2) | C25H48NO7P | 8.360 | 505.316 | 4.235 | 1.125 | 9.93E−05 | 0.690 |
| 16 | Methionine | C5H11NO2S | 1.253 | 149.051 | 1.097 | 0.869 | 6.15E−04 | 0.683 |
| 17 | Uric acid | C5H4N4O3 | 1.247 | 168.028 | 1.698 | 0.873 | 0.001 | 0.668 |
| 18 | LysoPE (20:4) | C25H44NO7P | 8.317 | 501.285 | 1.074 | 1.179 | 1.41E−04 | 0.668 |
| 19 | Testosterone sulfate | C19H28O5S | 8.194 | 368.165 | 2.104 | 0.724 | 0.016 | 0.660 |
| 20 | Hypoxanthine | C5H4N4O | 1.251 | 136.038 | 1.188 | 0.866 | 0.004 | 0.656 |
| 21 | Citric acid | C6H8O7 | 1.256 | 192.027 | 1.868 | 0.883 | 0.002 | 0.619 |
| 22 | 3-Indoxyl sulfate | C8H7NO4S | 4.818 | 213.009 | 1.934 | 0.710 | 0.014 | 0.604 |
| 23 | Arginine | C6H14N4O2 | 0.884 | 174.111 | 1.238 | 1.123 | 0.031 | 0.567 |