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. 2020 Sep 24;2(2):fcaa154. doi: 10.1093/braincomms/fcaa154

Figure 5.

Figure 5

Glycolytic EDL muscle fibre bundles from SOD1G93A mice are capable of utilizing glucose metabolism pathways. (A) Data traces of mitochondrial OCR (% of baseline) when carbonylcyanide-p-trifluoromethoxyphenylhydrazone (FCCP) was used to induce maximal mitochondrial respiration in the presence of (A) pyruvate (PY) or (B) palmitate (PA), followed by inhibition of the mitochondrial electron transport chain complexes III and I by antimycin a (AA) and rotenone (ROT). (C) Quantification of basal OCR in EDL muscle fibre bundles from SOD1G93A mice and WT age-matched control mice. (D) Quantification of area under the curve (AUC) of OCR in muscle fibre bundles from SOD1G93A and WT control mice in the presence of FCCP and pyruvate. (E) Quantification of AUC of OCR in muscle fibre bundles from SOD1G93A and WT controls in the presence of FCCP and palmitate. White circles represent WT mice; teal circles represent SOD1G93A transgenic mice. All data presented as mean ± SD for n = 5–11/group. *P < 0.05, two-way ANOVA with Bonferroni’s post hoc test. MS = mid-stage; OS = onset; PS = presymptomatic.