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. 2020 Aug 9;33(4):265–277. doi: 10.1293/tox.2020-0043

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©2020 The Japanese Society of Toxicologic Pathology

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/）.

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Fig. 3. — Histopathology of rats exposed to PHMG·HCl. In the nasal cavity, (A, B) No abnormal lesion was observed in the control (A) and 1 mg/m³ PHMG·HCl (B) groups. (C) Degeneration of respiratory epithelium (arrow) and transitional epithelium (arrowhead) in the 5 mg/m³ PHMG·HCl group. (D) Squamous metaplasia of respiratory epithelium (arrow) and transitional epithelium (arrowhead) in the 25 mg/m³ PHMG·HCl group. In the larynx, (E) No abnormal lesion was observed in the control group. (F, G) Squamous metaplasia of the epithelium (arrow), inflammation of the lamina propria (arrowhead) in 1 (F) and 5 mg/m³ (G) PHMG·HCl groups and ulcer of the epithelium (white arrow) in 5 mg/m³ (G) PHMG·HCl group. (H) Ulcer of the epithelium (arrow) and inflammation of the lamina propria (arrowhead) in the 25 mg/m³ PHMG·HCl groups. In the trachea, (I) No abnormal lesion was observed in the control group. (J, K) Degeneration of the epithelium (arrow) in 1(J) and 5 mg/m³ (K) PHMG·HCl groups. (L) Necrosis of the epithelium (arrow) in the 25 mg/m³ PHMG·HCl group. In the lung, (M) No abnormal lesion was observed in the control group. (N) Detachment of the bronchiolar epithelium (arrow) in the 1 mg/m³ PHMG·HCl group. (O) Squamous metaplasia of bronchiolar epithelium (arrow) in the 5 mg/m³ PHMG·HCl group. (P) Alveolar fibrosis (arrow) in the 25 mg/m³ PHMG·HCl group. Scale bars=100 μm, Magnification: ×200, H&E staining.