Fig. 1.

The effect of dacomitinib and gedatolisib on cell viability of HNSCC cell lines in vitro. In panel A western blots for EGFR expression are shown for four different HNSCC cell lines. In panel B, the effect of different concentrations of dacomitinib on cell viability of these cell lines is presented (n = 3 replicates, the error bars were excluded for clarity). In panel C, the effect of gedatolisib was studied in the most sensitive and most resistant cell lines to dacomitinib (n = 3 replicates).