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A schema of the hypothesis. miR-7-5p suppressed the activity of OGT by binding to the 3-UTR site of OGT, inhibiting the O-GlcNAcylation of oncoproteins. It could also regulate glucose metabolism through Akt, c-Myc, ChREBP, NF-κB, and HIF-1. Consequently, miR-7-5p inhibits cancer metabolism and the growth of cancer cells.
