Figure 4.
Scatter plots comparing the model predictions to the actual measurements of scan 3 for each patient (N = 18) along with the corresponding KCCs per group (see CCCs and PCCs in the text). The dashed line indicates the 45o line of unity. Note that for all 3 tumor response measures, there is greater correlation for the chemo subgroup compared to the chemo+ (i.e., patients that received chemotherapy plus targeted therapy or immunotherapy). Panel (a) depicts the comparison between the predicted total cell number to the measured total cell number as estimated from the DW-MRI data. Panel (b) depicts the comparison between the predicted total tumor volume to the measured tumor volume as determined by the total number of voxels in the tumor ROI. Panel (c) depicts the comparison of the predicted longest axis of the tumors to the actual measured longest axes as determined from the tumor ROI of scan 3. Note that using the log scale for panels (a) and (b), 1 patient is not shown where zero tumor was measured at the time of scan 3 (chemo subgroup, patient 4), but corresponding KCC values include this data.