Figure 5.

Comparison of the percent change in total tumor cellularity from scan 2 to the time of scan 3 achieved by the standard regimen, a one-half dose double frequency regimen, a one-third dose triple frequency regimen, a one-quarter dose quadruple frequency regimen, and an equivalent daily dose when administered daily to each patient (panel a). Across patients, differences in the percent change between the standard therapeutic regimen and the model-identified, most effective regimen have a maximum difference of 46%, a minimum difference of 0%, and a median difference of 17% (panel b). Note: a positive difference indicates a potential additional percent reduction in the total tumor cellularity achieved by the alternative regimen compared to the standard dose the patient received. The group of standard regimens was found to be statistically inferior to the group of optimal regimens selected for each patient for tumor control/reduction (P < 0.001 for percent change from scan 2 to 3 and for the predicted cell number at the time of scan 3). The most effective regimens by number of patients: standard N = 1, one-half N = 4, one-third N = 2, one-quarter N = 2, daily N = 4.