Table 2. Univariate and Multivariable Cox Analysis of Breast Cancer–Specific Survival in Patients With T1 N0 M0 Triple-Negative Breast Cancer.
| Characteristic | Patients, No. | Events, No. | Rate of events/patient, No. | Univariate analysis | Multivariable analysis | ||
|---|---|---|---|---|---|---|---|
| BCSS HR (95% CI) | P value | BCSS AHR (95% CI) | P value | ||||
| Age, y | |||||||
| 50-70 | 4328 | 133 | 3.07 | 1 [Reference] | 1 [Reference] | ||
| <35 | 173 | 9 | 5.20 | 1.705 (0.868-3.348) | .12 | 1.339 (0.672-2.670) | .41 |
| 35-50 | 1523 | 53 | 3.48 | 1.126 (0.819-1.548) | .47 | 0.964 (0.695-1.338) | .83 |
| ≥70 | 1715 | 75 | 4.37 | 1.474 (1.110-1.956) | .007 | 1.464 (1.074-1.996) | .02 |
| Race/ethnicity | |||||||
| Non-Hispanic White | 4997 | 164 | 3.28 | 1 [Reference] | 1 [Reference] | ||
| Non-Hispanic Black | 1377 | 61 | 4.43 | 1.396 (1.041-1.873) | .03 | 1.402 (1.037-1.895) | .03 |
| Non-Hispanic other races | 569 | 15 | 2.64 | 0.847 (0.499-1.437) | .54 | 0.841 (0.495-1.429) | .52 |
| Hispanic (all races) | 796 | 30 | 3.77 | 1.271 (0.861-1.876) | .23 | 1.226 (0.826-1.819) | .31 |
| Marital status | |||||||
| Married | 4790 | 158 | 3.30 | 1 [Reference] | 1 [Reference] | ||
| Single | 1064 | 38 | 3.57 | 1.082 (0.759-1.541) | .66 | 1.008 (0.702-1.446) | .97 |
| Divorced, separated, or widowed | 1885 | 74 | 3.93 | 1.170 (0.891-1.547) | .26 | 1.033 (0.773-1.381) | .83 |
| Grade | |||||||
| G1 | 276 | 2 | 0.72 | 1 [Reference] | 1 [Reference] | ||
| G2 | 1775 | 53 | 2.99 | 4.361 (1.063-17.89) | .04 | 4.044 (0.983-16.643) | .05 |
| G3 | 5644 | 211 | 3.74 | 5.567 (1.383-22.40) | .02 | 4.813 (1.188-19.495) | .03 |
| G4 | 44 | 4 | 9.09 | 12.171 (2.229-66.45) | .004 | 9.463 (1.720-52.046) | .01 |
| Stage | |||||||
| T1a | 755 | 9 | 1.19 | 1 [Reference] | 1 [Reference] | ||
| T1b | 1979 | 47 | 2.37 | 1.882 (0.923-3.841) | .08 | 1.982 (0.965-4.071) | .06 |
| T1c | 5005 | 214 | 4.28 | 3.551 (1.823-6.919) | <.001 | 3.568 (1.803-7.063) | <.001 |
| Surgery | |||||||
| Breast conserving | 5372 | 154 | 2.87 | 1 [Reference] | 1 [Reference] | ||
| Simple | 1798 | 86 | 4.78 | 1.718 (1.319-2.236) | <.001 | 1.889 (1.303-2.738) | <.001 |
| Radical | 463 | 27 | 5.83 | 1.795 (1.192-2.702) | .005 | 1.847 (1.146-2.977) | .01 |
| Other | 106 | 3 | 2.83 | 1.446 (0.461-4.537) | .53 | 1.826 (0.566-5.892) | .31 |
| Adjuvant therapy | |||||||
| None | 1286 | 64 | 4.98 | 1 [Reference] | 1 [Reference] | ||
| Chemotherapy | 2202 | 78 | 3.54 | 0.754 (0.542-1.050) | .09 | 0.657 (0.460-0.939) | .02 |
| Radiotherapy | 1278 | 31 | 2.43 | 0.467 (0.304-0.718) | <.001 | 0.805 (0.489-1.327) | .40 |
| Both | 2973 | 97 | 3.26 | 0.648 (0.473-0.889) | .007 | 0.895 (0.593-1.351) | .60 |
Abbreviations: AHR, adjusted hazard ratio; HR, hazard ratio.