Fig. 1.

Evodiamine inhibits growth and induced apoptosis in NSCLC cells. a The structures of evodiamine. b The human Lung adenocarcinoma cell lines cells were treated with evodiamine for 72 h and cell viability was detected by MTT assays. c-d H1650 and H1975 cells were treated with evodiamine for 24 h and the apoptosis was analyzed by flow cytometry. e Cleaved PARP was also detected (e), and the data show that cleaved PARP was significantly increased by evodiamine treatment for 24 h. f H650 and H1975 cells are treated for 24 h, and cell cycle distribution is analyzed using flow cytometry. The results were presented in three independent experiments with the mean ± S.D. (n = 3, *P < 0.05; **P < 0.01; ***P < 0.001)