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A hypothetical model describing the events by which differential DAP1 expression impacts endophenotypes of autoimmunity and susceptibility to SLE. Our model proposes that the HAP3 regulatory allele of DAP1 mediates lower transcription of autophagy-suppressing DAP1 protein, which results in enhanced autophagy, survival of autoreactive lymphocytes, enhanced antigen presentation, and development of autoimmunity
