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. 2020 Nov 18;17:346. doi: 10.1186/s12974-020-02026-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Soluble signals from microglia induced shifts in GBM12 cell transcriptome. a RNAseq and differential gene expression analysis (p < 0.05) identified 1563 upregulated genes and 1846 downregulated genes in GBM12 co compared to GBM12 single. Selected (b) gene ontology (GO) and (c) KEGG pathway terms suggest GBM-MG interactions underlie upregulated expression of genes involved in GBM proliferation and genes with diminished expression associated with GBM invasion. (n = 3 for GBM12 single and GBM12 co) (d) Significant putative genes from the top 50 genes with normalized enrichment score > 3 were identified via iRegulon