Table 4.
Test parameters for CF CB specimens compared to direct formalin fixation
| TPS cutoff ≥50% | TPS cutoff ≥1% | |
|---|---|---|
| Sensitivity | 95.2 (76.2, 99.9) | 96.8 (83.3, 99.9) |
| Specificity | 96.8 (83.3, 99.9) | 90.5 (69.6, 98.8) |
| Accuracy | 96.2 (86.8, 99.5) | 94.2 (84.1, 98.8) |
| PPV | 95.2 (76.2, 99.9) | 93.8 (79.2, 99.2) |
| NPV | 96.8 (83.3, 99.9) | 95.0 (75.1, 99.9) |
| FPR | 3.2 (o.1, 16.7) | 9.5 (1.2, 30.4) |
| FNR | 4.8 (0.1, 23.8) | 3.2 (0.1, 16.7) |
All values are in percentage (%) and 95% confidence intervals are within parentheses. CF, CytoLyt®-prefixed; CB, cell block; TPS, tumor proportion score; FNR, false-negative rate; FPR, false-positive rate; NPV, negative predictive value; PPV, positive predictive value.