Table 3.
Pharmacokinetic parameters of levamlodipine test and reference formulations in the fed group (n = 24)
| Parameter | Arithmetic mean ± SD (%CV)a | |
|---|---|---|
| T | R | |
| Cmax/μg × L−1 | 2.73 ± 0.547 (20.1%) | 2.87 ± 0.812 (28.3%) |
| AUC0–t/μg × h × L− 1 | 166.93 ± 49.96 (29.93%) | 165.46 ± 43.58 (26.34%) |
| AUC0–∞/μg × h × L− 1 | 190.99 ± 70.89 (37.12%) | 189.51 ± 64.70 (34.14%) |
| T1/2/h | 53.38 ± 10.99 (20.58%) | 53.56 ± 13.41 (25.05%) |
| tmax*/h | 7.00 (5.00, 14.00) | 7.00 (2.00, 24.00) |
aAll values are represented as arithmetic mean ± standard deviation (CV, %) with [geometric mean] unless otherwise specified. *tmax is shown as median (minimum-maximum)