Table 1.

List of common variants that significantly associated with brain imaging features (P < 1.0 × 10⁻³)

AD imaging biomarker	Data type	Chr:position (hg19)	dbSNP ID	Genea	PFb	Previously reported	P
I. Cerebral amyloid-β accumulation measured by PiB-PET
Aβ deposition	Bin.c	chr3:39138840	rs3732377	GORASP1	0.237	Novel	9.32 × 10−4
		chr3:39139776	rs1109643	GORASP1	0.161	Novel	9.79 × 10−4
		chr3:39149277	rs28362644	GORASP1	0.162	Novel	7.02 × 10−4
		chr11:47345916	rs2290149	MADD	0.082	Novel	2.02 × 10−4
	Quant.d	chr12:130839165	rs10848087	PIWIL1	0.105	Novel	5.05 × 10−4
II. Glucose metabolism levels measured by FDG-PET
AD-Cm	Bin.	chr1:227077809	rs75733498	PSEN2	0.083	Novel	1.75 × 10−4
	Quant.	chr7:37890267	rs2722372	NME8	0.191	Novel	7.63 × 10−4
PCC-Cm	Quant.	chr7:37890267	rs2722372	NME8	0.191	Novel	5.71 × 10−4
III. Cortical thickness measured by MRI
AD-Ct	Bin.	chr14:73686944	rs7523	PSEN1	0.161	Novel	1.74 × 10−5
	Quant.	chr12:130839165	rs10848087	PIWIL1	0.105	Novel	2.94 × 10−4
IV. Hippocampal volume reduction measured by MRI
Hv	Quant.	chr20:55033476	rs3746623	CASS4	0.945	Novel	1.73 × 10−4
		chr20:55033647	rs3746625	CASS4	0.946	Novel	1.73 × 10−4
		chr20:55033713	rs3746626	CASS4	0.946	Novel	1.73 × 10−4
		chr20:55033856	rs4811697	CASS4	0.946	Known [27]	3.42 × 10−4
	Both	chr12:130839165	rs10848087	PIWIL1	0.105	Novel	4.24 × 10−4

^aThe most closely located gene from each variant

^bPopulation frequency in the KBASE cohort

^cCategorical variable trait transformed from normalized neuroimaging data by each criterion

^dQuantitative normalized neuroimaging variable trait